Beta actin antibody/ β-Actin抗體
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- 公司名稱 上海優寧維生物科技股份有限公司
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上海優寧維生物科技股份有限公司（簡稱：優寧維，代碼：301166）自2004年成立以來一直專注于抗體及相關產品，是國內專業、全面的抗體供應商和抗體專家，十多年來，已逐漸發展成為生命科學一站式供應商。
我們長期聚焦于生命科學、生物醫藥、醫療診斷、分析檢測等領域，公司整合了國內外50多家行業品牌，提供400多萬種以抗體為核心的生命科學試劑、耗材、儀器、軟件、定制、實驗室服務、供應鏈服務等，形成了以第三方品牌產品為主、自主品牌產品為輔的全面供應體系，為更多的生命科學科研工作者提供專業、全面、安全、快捷的產品和服務。產品覆蓋基因、蛋白、細胞、組織、動物等水平的各種研究。
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| 概述 | |
| 描述 | Actin, a ubiquitous eukaryotic protein, is the major component of the cytoskeleton. At least six isoforms are known in mammals. Nonmuscle β- and γ-actin, also known as cytoplasmic actin, are predominantly expressed in nonmuscle cells, controlling cell structure and motility. |
| 別名 | β-Actin抗體 |
| 宿主 | Rabbit |
| 特異性 | Beta actin antibody detects endogenous levels of total Beta actin. |
| 反應種屬 | Human;Mouse;Rat;Pig;Zebrafish;Dog;Monkey;Fish |
| 預測反應種屬 | Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse; |
| 應用 | WB 1:3000-1:20000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000 |
| 免疫原 | A synthesized peptide derived from human Beta actin. |
| 性能 | |
| 濃度 | 1mg/ml |
| 純化方法 | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| 類型 | Polyclonal Antibody |
| 儲存/保存方法 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| 存儲溶液 | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
| 靶標 | |
| 背景說明 | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| 翻譯后修飾 | ISGylated.Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-50 of one monomer and Glu-270 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148). |
| 細胞定位 | Cytoskeleton;Cytosol;Extracellular region or secreted;Nucleus;Plasma Membrane; |
| UniProt | P60709 |
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