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BPS Bioscience Inc.
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Romidepsin (FK228, depsipeptide)

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品       牌BPS Bioscience

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更新時(shí)間:2023-12-19 23:34:26瀏覽次數(shù):130次

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保存條件:Roomtemp
  • 保存條件:

    Room temp. (continental US) or gel packs

  • 保質(zhì)期:

    Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

  • 英文名:

    Romidepsin (FK228, depsipeptide)

  • 數(shù)量:

    1

  • 供應(yīng)商:

    BPS Bioscience Inc.

  • CAS號(hào):

    /

  • 規(guī)格:

    1 mg

Romidepsin, also known as FK228 or depsipeptide, is a potent and selective inhibitor of HDAC1 and HDAC2 , which are associated with the regulation of re-expression of silenced tumor suppressor genes. It was the first HDAC inhibitor to manifest anti-tumor activity and originally isolated from a rod-shaped Gram-negative bacterium, Chromobacterium violaceum, found in a Japanese soil sample. Romidepsin exhibits a stronger inhibition towards HDAC1 and HDAC2 enzymes (class I), removing acetyl groups from the lysine residues of N-terminal histone tails and maintaining a more open and transcriptionally active chromatin state, than HDAC4 and HDAC6 enzymes (class II). Besides HDAC inhibition, romidepsin is also able to induce cell cycle arrest, cellular differentiation, apoptosis and alteration of gene expression in adult malignancies.
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